What is CBD?

Molecular structure of cannabidiol (CBD)

Cannabidiol (CBD) is a part of a class of chemicals found in the cannabis plant known as cannabinoids. These chemicals interact with a system within the human body known as the endocannabinoid system (ECS). The ECS refers to a collection of receptors found both in the brain and elsewhere in the body. The CB1 receptor is found primarily in the brain, while the CB2 receptor is mostly found in microglia, a type of cell located throughout the brain and spinal cord, where they are involved in active immune defense in the central nervous system.

The ECS has been a field of intense research in recent years and there is evidence it influences a range of functions, including sleep, mood, appetite, memory and perception. THC is the best known cannabinoid, and is understood to be a partial agonist of both CB1 and CB2 receptors, with well documented psychoactive effects such as perception, mood, consciousness and behaviour.

How CBD interacts with CB1 and CB2 receptors is less well understood, but the quantity of research increases significantly each year. What is understood is that it has no psychoactive effect, and yet has shown significant promise in the treatment of a number of medical conditions, ranging from anxiety, insomnia, inflammation, and even epilepsy. 

THC is illegal in many jurisdictions. Even where THC is legal for medical or recreational use, it remains prohibited for use by athletes. Biosportart products will never contain any trace of THC, other illegal or WADA prohibited chemicals.  

What is CBD good for?

And why don’t make any claims like other websites do?

Biosportart intends to be a long term producer of high-quality formulations for European and Asian sports and athletics markets. We don’t make claims simply because despite a large body of research (and an even larger volume of anecdotal data), there is not yet the clinical trial data to support medical claims, and therefore any claims could be construed as to violate European law, where we also operate.

One of the main reasons there are few large scale clinical trials of CBD is because it is a naturally occurring molecule and therefore cannot be patented. Large scale trials are expensive, and most large pharmaceutical companies are focussed on discovering new, patentable drugs, that offer multi-decade financial returns. However, Biosportart are in discussions with PureForm on future clinical trials.

Many suppliers currently making claims will likely disappear if and when the regulators seek to enforce existing laws regarding supported claims. Due to the high inconsistency of cannabis CBD supply, it is likely that many of these suppliers are already violating UK law.

What is synthesized bio-identical CBD?

Bio-identical is a way of saying identical. Synthesized bio-identical CBD (cannabidiol) is CBD that is not extracted from the cannabis plant, but rather ‘synthesized’ from other base materials using organic chemistry. In the case of PureForm Global CBD, the base material is a citrus (orange) terpene.

Synthesized bio-identical CBD is identical in every way to naturally occurring CBD that is itself synthesized by the cannabis sativa plant.

While ‘synthetic bio-identical CBD’ may sound less natural than ‘plant extract CBD’ or ‘hemp oil CBD’, the process actually uses less chemicals than solvent and gas extraction. There is also no risk of residual fertilizers and herbicides and no risk of mycotoxins – potentially deadly toxins produced by fungi that often colonize cannabis crops.
Consistency, purity, and safety are the key challenges facing the CBD industry. Reliable at-scale synthesis is a critical step in broader clinical adoption of cannabidiol.

PureForm CBD is bio-identical CBD and not an analogue

It is important to state that PureForm CBD is bio-identical to CBD and not an analogue (acting on the same receptor). All the negative information about synthetic cannabinoids, are actually referring to synthetic cannabinoid analogues. They refer to compounds, such as spice, that do not occur in nature and are illegal. Cannabidiol (CBD), be it synthesized from citrus terpenes, grown from yeast, or gas extracted from cannabis is identical. The only difference is that CBD from cannabis contains residual cannabinoids.

It is this reason the EU mandates that all cosmetic products must used pure synthesized CBD and not hemp – see the article Choosing Cosmetic Ingredients – European Industrial Hemp Association below. However, Biosportart does not support this restriction and believes formulators should be able to chose to use cannabis extracted CBD if they wish.

Choosing Cosmetic Ingredients – European Industrial Hemp Association
https://eiha.org/cosing-cosmetics-ingredients/

Forget Growing Weed—Make Yeast Spit Out CBD and THC Instead
https://www.wired.com/story/yeast-cbd-and-thc/

PureForm CBD it is identical to cannabis derived CBD and interacts with the Endocannabinoid system (ECS) in precisely the same way as the naturally occurring molecule.

Is CBD Safe?

CBD is widely considered safe, even at large oral doses of several thousand milligrams per day. As an externally applied cream the risk is reduced further, even with Biosportart’s high concentration creams and gels. To date, no customer has informed us of any side-effects. Furthermore, a 2017 World Health Organization report on CBD declared:

“Across a number of controlled and open label trials CBD of the potential therapeutic effects of CBD it is generally well tolerated, with a good safety profile.
World Health Organization 
CANNABIDIOL (CBD) Pre-Review Report Agenda Item 5.2
https://www.who.int/medicines/access/controlled-substances/5.2_CBD.pdf

Furthermore, the WHO report found that CBD is not addictive and recreational use has not created any public health issues.

“To date, there is no evidence of recreational use of CBD or any public health related problems associated with the use of pure CBD.”
CANNABIDIOL (CBD) Pre-Review Report Expert Committee on Drug Dependence Thirty-ninth Meeting Geneva, 6-10 November 2017
https://www.who.int/medicines/access/controlled-substances/5.2_CBD.pdf

In clinical studies of Epidiolex, an orally administered FDA approved CBD medicine, some patients did withdraw due to interactions with other medications and others with abnormal liver activity. There is no evidence that this applies to externally applied creams and gels such as Biosportart products, but you should always follow the product usage guidelines and consult your doctor before use if pregnant, breastfeeding, taking a prescription drug, or have a serious medical condition.

Why isn’t CBD more widely available?

Major supplement, cosmetic and pharmaceutical companies are waiting until strong claims in efficacy can be made. However, claims in efficacy require evidence of repeatable and demonstrable effects – which is extremely challenging without a consistent ingredient. Currently, CBD extracted from cannabis can be inconsistent in quality, with multiple tests run on the same batch of CBD isolate producing wildly different results.

Synthesized CBD products such as PureForm CBD have none of these purity and consistency challenges. PureForm CBD will undoubtedly play a vital role in the future adoption of CBD in mainstream medicine and Biosportart is proud to be an early partner with a company with such disruptive potential.

For more information, or answers to the mostly commonly asked questions, please see: Your CBD questions, answered

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